Hematological indices and abnormalities in malaria infected albino model treated with Artemisia annua extract and chloroquine therapy
1 Department of Parasitology, Dubai Medical College, Dubai, United Arab Emirates.
2 Department of Biochemistry, Dubai Medical College, Dubai, United Arab Emirates.
3 Department of Pathology, Dubai Medical College, Dubai, United Arab Emirates.
Research Article
Open Access Research Journal of Science and Technology, 2022, 04(02), 034–041.
Article DOI: 10.53022/oarjst.2022.4.2.0036
Publication history:
Received on 11 February 2022; revised on 21 March 2022; accepted on 23 March 2022
Abstract:
Malaria disease can be categorized as uncomplicated or severe (complicated). In general, malaria is a curable disease if diagnosed and treated promptly and correctly. All the clinical symptoms associated with malaria are caused by the asexual erythrocytic or blood stage parasites. Malaria is caused by the Plasmodium parasite. The parasite can be spread to humans through the bites of infected mosquitoes. Artemisinin derivatives are an important new class of antimalarial agents. These compounds contain endoperoxide bridges which are essential for antimalarial activity. The aim of this study was to evaluate the effect of both Ethanolic and watery extract of Artemisinin against malaria infected mice. Blood was taken from a donor mouse with parasitemia Plasmodium falciparum and diluted using saline to 5 × 107 parasitized erythrocytes per ml. Swiss albino mice were infected with 0.2 ml blood., Ethanolic, and water extract of Artemisinin Annua in addition to traditional chloroquine were used in treatment of mice after inoculation with infected blood with plasmodium. In our study there were increase in both red blood cells in Art. Annuna Ethanol Extract Art. Annuna Water Extract and Chloroquine treatment groups with values 7.48 ± 0.52, 8.7 ± 0.24, 9.9 ± 0.51, and 4.05 ± 0.8. This study indicates that the treatment of malaria using Artemisia annua results in improved hematological indices.
Keywords:
Plasmodium; Artemisinin Annuna; Hemoglobin
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