3, 5-disubstituted 1,2,4- oxadiazole: A potent inhibitor of Mycolic acid synthesis
Department. of Pharmaceutical Chemistry, Mar Dioscorus College of Pharmacy, Alathara, Thiruvananthapuram, Kerala-695017, India.
Research Article
Open Access Research Journal of Science and Technology, 2023, 09(01), 037–042.
Article DOI: 10.53022/oarjst.2023.9.1.0052
Publication history:
Received on 14 July 2023; revised on 17 September 2023; accepted on 20 September 2023
Abstract:
Oxadiazoles are 5-membered, unsaturated, unstable, heteroaromatic ring containing two carbon atom, one oxygen atom and two pyridine type nitrogen atom linked in continuity. They fall under non beta lactam class of antibiotics. Oxadiazoles are potent inhibitors of mycolic acid synthesis. Mycolic acids are long fatty acids important for cell wall formation in class of bacterias called Mycolata taxon. The article focuses on various scaffolds of 1, 2, and 4- oxadiazole having inhibitory action on mycolic acid synthesis and can be applied for anti-tuberculosis treatment.
Keywords:
Oxadiazole; Non beta Lactam antibiotics; Mycolic acid; Mycobacterium tuberculosis
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